Oxy-R Peptides
A professional-strength brightening serum featuring 1% stabilized oxyresveratrol - 33x more effective than kojic acid at inhibiting tyrosinase. This innovative formula combines twin brightening peptides with hyaluronic acid to visibly fade dark spots and even skin tone in as little as 7 days. Patented click-activated packaging ensures maximum potency from first drop to last.
β¨ Texture & Feel
Patented Stabilization System
Click-activated packaging keeps oxyresveratrol stable and potent from first use to last drop - a breakthrough for this notoriously unstable ingredient.
Triple-Threat Brightening
Combines 1% Oxy-R with two brightening peptides (Tetrapeptide-30 & Acetyl Glycyl Beta-Alanine) for comprehensive pigmentation targeting.
All Skin Tones
Clinically tested on diverse panels including Fitzpatrick 5-6 skin types, proving effective and gentle on deeper skin tones.
33x More Effective Than Kojic Acid
Oxyresveratrol is a superior tyrosinase inhibitor according to Journal of Biological Chemistry research.
π‘οΈ Safety & Compatibility
Medik8 advises consulting your GP or midwife before use. While formula contains no known harmful ingredients (no retinoids, high-strength acids), always verify with healthcare provider.
Free from oils, fatty acids, ferments, and polysorbates. Verified fungal acne safe by multiple ingredient analysis databases.
92% of participants in clinical studies found it gentle on their skin. Oxyresveratrol is non-irritating and non-sensitizing.
Does not increase photosensitivity. Safe for AM and PM use. Always use SPF during daytime for best results.
π¬ Ingredient Breakdown
πΏ Oxyresveratrol (Hydroxyresveratrol) 1% Gold-Standard
Naturally derived from the mulberry family, this is one of the most powerful skin-brightening agents available in skincare. It works by inhibiting tyrosinase, the key enzyme responsible for melanin production.
- Research: 33x more effective tyrosinase inhibitor than kojic acid (Journal of Biological Chemistry, 2002)
- Mechanism: Blocks overproduction of melanin that causes dark spots and uneven tone
- Stability: Housed in patented preservation serum in lid until click-activated
𧬠Tetrapeptide-30 0.15-0.55% Proven
An illuminating four-amino-acid peptide that helps minimize the formation of visible dark spots through dual action on the pigmentation pathway.
- Action 1: Acts as a tyrosinase inhibitor to reduce melanin production
- Action 2: Blocks transfer of melanin to upper skin layers
- Clinical Testing: Tested on Caucasian, Asian, and ethnic skin with positive results
β‘ Acetyl Glycyl Beta-Alanine Promising
A brightening peptide that works synergistically with Oxy-R by targeting a different part of the pigmentation process.
- Mechanism: Blocks melanin transport to skin cells, preventing visible pigmentation
- Synergy: Complements Oxy-R for comprehensive "triple-threat" approach
π§ Sodium Hyaluronate 0.55-1.25% Proven
Low molecular weight hyaluronic acid that attracts and retains over 1,000 times its weight in water for deep hydration.
- Function: Delivers hydrating base while optimizing delivery of active ingredients
- Benefit: Leaves complexion visibly nourished and supple
π Gluconolactone (PHA) 2.1-3.1% Gentle
A gentle polyhydroxy acid that provides mild exfoliation without irritation, suitable for sensitive skin.
- Action: Gentle exfoliation helps shed dead cells for smoother skin
- Benefit: Stimulates skin's own hyaluronic acid production
π₯ Lactic Acid (AHA) 0.9-1.4% Gentle
Low concentration alpha hydroxy acid that supports the skin's natural acid mantle and provides humectant benefits.
- Note: Concentration too low for strong exfoliation - works as humectant instead
- pH Optimized: Formula pH designed to minimize degradation of alpha arbutin
15 ingredients
Aqua (Water), Butylene Glycol, Artocarpus Lakoocha Wood Extract, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium EDTA, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
π Where It Fits in Your Routine
Apply after cleansing, before Vitamin C (AM) or Vitamin A/Retinal (PM). Perfect CSA routine booster.
π How to Use
Activate the Serum (First Use Only)
Press down firmly on bottle lid until it clicks. Shake for 30 seconds to blend the Oxy-R into the formula. Recycle lid and replace with dropper.
Cleanse Your Skin
Start with clean, dry skin. Use morning and evening for best results.
Apply 6 Drops
Blend across face, neck, and dΓ©colletage. Avoid the eye area. The serum will have a brown color - this is normal and indicates active Oxy-R.
Allow to Absorb
Wait for serum to fully absorb before applying next products. Follow with Vitamin C (AM) or Vitamin A (PM), then moisturizer.
π€ Who Is It For?
β Perfect for you if:
- You have dark spots from sun damage or aging
- You struggle with post-inflammatory hyperpigmentation (PIH)
- You have uneven skin tone or dullness
- You have melasma concerns
- You want to boost your Vitamin C & A routine
- You have deeper skin tones (Fitzpatrick 4-6)
- You prefer fragrance-free, gentle formulas
β Consider alternatives if:
- You need a budget-friendly option (premium price point)
- You prefer all-in-one products (this is a targeted treatment)
- You want immediate overnight results (patience required)
- You cannot commit to consistent daily use
- You need a product with longer shelf life after opening
π― Skin Type Compatibility
Lightweight, water-based formula absorbs instantly without adding shine or greasiness. Oil-free and silicone-free.
Contains hyaluronic acid and glycerin for hydration, but pair with a rich moisturizer for optimal comfort.
Balances perfectly across different face zones. Hydrates dry areas without overwhelming oily zones.
92% found it gentle in clinical studies. Fragrance-free, non-irritating formula. Patch test recommended for very reactive skin.
Non-comedogenic (0/5 rating), fungal acne safe, oil-free. Ideal for post-acne marks and PIH.
π Results Timeline
Visible Brightness
Skin appears visibly brighter with improved radiance. Hydration levels boosted from hyaluronic acid.
Visible brightness in 7 days*Dark Spot Fading
Post-inflammatory hyperpigmentation and recent dark spots begin to visibly fade. Skin tone appears more even.
Dark spots faded after 4 weeks*Significant Improvement
Clinically proven improvement in overall even tone. Stubborn spots continue to fade with consistent use.
Even tone improved in 8 weeks*Maximum Results
Full benefits realized with continued use. Maintenance application recommended for long-term results.
92% found it gentle on skin*β Ratings by Platform
βοΈ Pros & Cons
β Praised
- Unique 1% oxyresveratrol - highest concentration available
- Patented stabilization ensures potency
- Suitable for all skin tones including deep skin
- Fragrance-free and non-irritating
- Can use with Vitamin C and retinoids
- Lightweight, fast-absorbing texture
- Clinically proven results
- B Corp certified, sustainable brand
β Criticized
- Premium price point (~Β£65/20ml)
- Short 6-week shelf life after opening
- Results require patience (weeks to months)
- Small bottle size for the price
- Click-activation can be confusing
- Brown color after activation unexpected
- Two-bottle system requires remembering to activate second
π° Budget-Friendly Alternatives (Dupes)
Different brightening mechanism (alpha arbutin vs oxyresveratrol) but similar dark spot targeting. Lacks peptides and patented stabilization. Much more affordable for testing brightening serums.
Uses tranexamic acid (3%), niacinamide (5%), and bakuchiol instead of oxyresveratrol. Well-researched alternative approach to hyperpigmentation. Larger 30ml size with longer shelf life.
Uses Viniferine (vine sap extract) claimed to be 62x more effective than Vitamin C. Pregnancy-safe alternative. Different mechanism but similar brightening goals. Larger 30ml bottle.
π Comparison with Competitors
Medik8 Oxy-R Peptides (This Product)
Β£65.00Paula's Choice Clinical Discoloration Repair
$48.00The Ordinary Alpha Arbutin 2% + HA
$12.90Caudalie Vinoperfect Serum
$79.00π¦ Storage & Shelf Life
6 weeks per bottle after activation. Two bottles provided for 12 weeks total treatment. Activate second bottle only when first is finished.
Store at room temperature away from windows and direct sunlight. Keep both bottles at consistent temperature for optimal efficacy.
Patented click-activated dropper bottles. Oxy-R stored separately in lid until activation to preserve stability.
Yes - each 10ml bottle is under 100ml TSA/airline limit. Glass dropper bottles require careful packing.
β Frequently Asked Questions
Medik8 states they cannot provide medical advice regarding pregnancy. However, the formula contains no retinoids, high-strength acids, or known harmful ingredients. The low-level PHAs and AHAs (under 3%) are generally considered gentle. Always consult your GP, midwife, or obstetrician before using any new skincare during pregnancy or nursing. Peptides are generally considered safe during pregnancy.
Yes! This serum is verified fungal acne safe by multiple ingredient analysis databases. It's free from oils, fatty acids, ferments, polysorbates, and other ingredients that feed malassezia yeast. The water-based, oil-free formula makes it an excellent choice for those with fungal acne concerns.
Absolutely! Oxy-R Peptides is designed to boost Medik8's CSA (Vitamin C, Sunscreen, Vitamin A) philosophy. In the AM, apply Oxy-R Peptides after cleansing, then your Vitamin C serum, then SPF. In the PM, apply after cleansing, then your retinol or Crystal Retinal. It can also be used with AHAs and BHAs, though introduce slowly to avoid over-exfoliation.
Oxy-R Peptides is suitable for all skin types including sensitive skin - 92% of clinical study participants found it gentle. It's particularly excellent for oily, combination, and acne-prone skin due to its lightweight, oil-free, non-comedogenic formula. Dry skin types should pair with a hydrating moisturizer.
Clinical studies show visible brightness in 7 days. Dark spots begin fading after 4 weeks of consistent use. Significant improvement in overall even tone is clinically proven at 8 weeks. Results vary based on the type and age of pigmentation - recent post-inflammatory marks respond faster than older sun damage or hormonal melasma.
Apply Oxy-R Peptides after cleansing (and toning if you use one), before serums, moisturizers, and SPF. Use 6 drops twice daily - morning and evening. In AM: Cleanser β Oxy-R Peptides β Vitamin C β Moisturizer β SPF. In PM: Cleanser β Oxy-R Peptides β Retinol/Retinal β Moisturizer.
No! Oxy-R Peptides has a comedogenic rating of 0/5. The formula is oil-free, silicone-free, and contains no pore-clogging ingredients. It's water-based with lightweight humectants like hyaluronic acid and glycerin. It's ideal for acne-prone skin and won't contribute to breakouts or congestion.
Each 10ml bottle stays potent for 6 weeks after click-activation. The product comes with two bottles for 12 weeks total treatment. Only activate the second bottle when you finish the first. Store at room temperature away from windows. The short shelf life is due to oxyresveratrol's instability - this is why the patented packaging exists.
This is completely normal! Oxyresveratrol is naturally brown when active in water. Once you click-activate the packaging and the Oxy-R plunges into the water-based solution, the serum takes on a deep brown color. This indicates the active ingredient is now working - it's a sign of potency, not a defect.
No, Oxy-R Peptides does not increase photosensitivity. It's safe for use in both morning and evening routines. However, always use SPF during the day when treating hyperpigmentation - sun exposure is the primary cause of dark spots and will counteract your brightening efforts.
Verdict: Medik8 Oxy-R Peptides is a genuinely innovative brightening serum featuring the highest concentration of stabilized oxyresveratrol available. The patented click-activation technology solves a real formulation challenge, and clinical studies support its efficacy across all skin tones. While the premium price and short shelf life may deter some, those serious about targeting stubborn hyperpigmentation will find this a worthwhile investment. Best for users who can commit to consistent use and want a gentle yet powerful alternative to traditional brightening ingredients like hydroquinone or high-strength Vitamin C.
Original: $67.00
-70%$67.00
$20.10Oxy-R Peptides
A professional-strength brightening serum featuring 1% stabilized oxyresveratrol - 33x more effective than kojic acid at inhibiting tyrosinase. This innovative formula combines twin brightening peptides with hyaluronic acid to visibly fade dark spots and even skin tone in as little as 7 days. Patented click-activated packaging ensures maximum potency from first drop to last.
β¨ Texture & Feel
Patented Stabilization System
Click-activated packaging keeps oxyresveratrol stable and potent from first use to last drop - a breakthrough for this notoriously unstable ingredient.
Triple-Threat Brightening
Combines 1% Oxy-R with two brightening peptides (Tetrapeptide-30 & Acetyl Glycyl Beta-Alanine) for comprehensive pigmentation targeting.
All Skin Tones
Clinically tested on diverse panels including Fitzpatrick 5-6 skin types, proving effective and gentle on deeper skin tones.
33x More Effective Than Kojic Acid
Oxyresveratrol is a superior tyrosinase inhibitor according to Journal of Biological Chemistry research.
π‘οΈ Safety & Compatibility
Medik8 advises consulting your GP or midwife before use. While formula contains no known harmful ingredients (no retinoids, high-strength acids), always verify with healthcare provider.
Free from oils, fatty acids, ferments, and polysorbates. Verified fungal acne safe by multiple ingredient analysis databases.
92% of participants in clinical studies found it gentle on their skin. Oxyresveratrol is non-irritating and non-sensitizing.
Does not increase photosensitivity. Safe for AM and PM use. Always use SPF during daytime for best results.
π¬ Ingredient Breakdown
πΏ Oxyresveratrol (Hydroxyresveratrol) 1% Gold-Standard
Naturally derived from the mulberry family, this is one of the most powerful skin-brightening agents available in skincare. It works by inhibiting tyrosinase, the key enzyme responsible for melanin production.
- Research: 33x more effective tyrosinase inhibitor than kojic acid (Journal of Biological Chemistry, 2002)
- Mechanism: Blocks overproduction of melanin that causes dark spots and uneven tone
- Stability: Housed in patented preservation serum in lid until click-activated
𧬠Tetrapeptide-30 0.15-0.55% Proven
An illuminating four-amino-acid peptide that helps minimize the formation of visible dark spots through dual action on the pigmentation pathway.
- Action 1: Acts as a tyrosinase inhibitor to reduce melanin production
- Action 2: Blocks transfer of melanin to upper skin layers
- Clinical Testing: Tested on Caucasian, Asian, and ethnic skin with positive results
β‘ Acetyl Glycyl Beta-Alanine Promising
A brightening peptide that works synergistically with Oxy-R by targeting a different part of the pigmentation process.
- Mechanism: Blocks melanin transport to skin cells, preventing visible pigmentation
- Synergy: Complements Oxy-R for comprehensive "triple-threat" approach
π§ Sodium Hyaluronate 0.55-1.25% Proven
Low molecular weight hyaluronic acid that attracts and retains over 1,000 times its weight in water for deep hydration.
- Function: Delivers hydrating base while optimizing delivery of active ingredients
- Benefit: Leaves complexion visibly nourished and supple
π Gluconolactone (PHA) 2.1-3.1% Gentle
A gentle polyhydroxy acid that provides mild exfoliation without irritation, suitable for sensitive skin.
- Action: Gentle exfoliation helps shed dead cells for smoother skin
- Benefit: Stimulates skin's own hyaluronic acid production
π₯ Lactic Acid (AHA) 0.9-1.4% Gentle
Low concentration alpha hydroxy acid that supports the skin's natural acid mantle and provides humectant benefits.
- Note: Concentration too low for strong exfoliation - works as humectant instead
- pH Optimized: Formula pH designed to minimize degradation of alpha arbutin
15 ingredients
Aqua (Water), Butylene Glycol, Artocarpus Lakoocha Wood Extract, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium EDTA, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
π Where It Fits in Your Routine
Apply after cleansing, before Vitamin C (AM) or Vitamin A/Retinal (PM). Perfect CSA routine booster.
π How to Use
Activate the Serum (First Use Only)
Press down firmly on bottle lid until it clicks. Shake for 30 seconds to blend the Oxy-R into the formula. Recycle lid and replace with dropper.
Cleanse Your Skin
Start with clean, dry skin. Use morning and evening for best results.
Apply 6 Drops
Blend across face, neck, and dΓ©colletage. Avoid the eye area. The serum will have a brown color - this is normal and indicates active Oxy-R.
Allow to Absorb
Wait for serum to fully absorb before applying next products. Follow with Vitamin C (AM) or Vitamin A (PM), then moisturizer.
π€ Who Is It For?
β Perfect for you if:
- You have dark spots from sun damage or aging
- You struggle with post-inflammatory hyperpigmentation (PIH)
- You have uneven skin tone or dullness
- You have melasma concerns
- You want to boost your Vitamin C & A routine
- You have deeper skin tones (Fitzpatrick 4-6)
- You prefer fragrance-free, gentle formulas
β Consider alternatives if:
- You need a budget-friendly option (premium price point)
- You prefer all-in-one products (this is a targeted treatment)
- You want immediate overnight results (patience required)
- You cannot commit to consistent daily use
- You need a product with longer shelf life after opening
π― Skin Type Compatibility
Lightweight, water-based formula absorbs instantly without adding shine or greasiness. Oil-free and silicone-free.
Contains hyaluronic acid and glycerin for hydration, but pair with a rich moisturizer for optimal comfort.
Balances perfectly across different face zones. Hydrates dry areas without overwhelming oily zones.
92% found it gentle in clinical studies. Fragrance-free, non-irritating formula. Patch test recommended for very reactive skin.
Non-comedogenic (0/5 rating), fungal acne safe, oil-free. Ideal for post-acne marks and PIH.
π Results Timeline
Visible Brightness
Skin appears visibly brighter with improved radiance. Hydration levels boosted from hyaluronic acid.
Visible brightness in 7 days*Dark Spot Fading
Post-inflammatory hyperpigmentation and recent dark spots begin to visibly fade. Skin tone appears more even.
Dark spots faded after 4 weeks*Significant Improvement
Clinically proven improvement in overall even tone. Stubborn spots continue to fade with consistent use.
Even tone improved in 8 weeks*Maximum Results
Full benefits realized with continued use. Maintenance application recommended for long-term results.
92% found it gentle on skin*β Ratings by Platform
βοΈ Pros & Cons
β Praised
- Unique 1% oxyresveratrol - highest concentration available
- Patented stabilization ensures potency
- Suitable for all skin tones including deep skin
- Fragrance-free and non-irritating
- Can use with Vitamin C and retinoids
- Lightweight, fast-absorbing texture
- Clinically proven results
- B Corp certified, sustainable brand
β Criticized
- Premium price point (~Β£65/20ml)
- Short 6-week shelf life after opening
- Results require patience (weeks to months)
- Small bottle size for the price
- Click-activation can be confusing
- Brown color after activation unexpected
- Two-bottle system requires remembering to activate second
π° Budget-Friendly Alternatives (Dupes)
Different brightening mechanism (alpha arbutin vs oxyresveratrol) but similar dark spot targeting. Lacks peptides and patented stabilization. Much more affordable for testing brightening serums.
Uses tranexamic acid (3%), niacinamide (5%), and bakuchiol instead of oxyresveratrol. Well-researched alternative approach to hyperpigmentation. Larger 30ml size with longer shelf life.
Uses Viniferine (vine sap extract) claimed to be 62x more effective than Vitamin C. Pregnancy-safe alternative. Different mechanism but similar brightening goals. Larger 30ml bottle.
π Comparison with Competitors
Medik8 Oxy-R Peptides (This Product)
Β£65.00Paula's Choice Clinical Discoloration Repair
$48.00The Ordinary Alpha Arbutin 2% + HA
$12.90Caudalie Vinoperfect Serum
$79.00π¦ Storage & Shelf Life
6 weeks per bottle after activation. Two bottles provided for 12 weeks total treatment. Activate second bottle only when first is finished.
Store at room temperature away from windows and direct sunlight. Keep both bottles at consistent temperature for optimal efficacy.
Patented click-activated dropper bottles. Oxy-R stored separately in lid until activation to preserve stability.
Yes - each 10ml bottle is under 100ml TSA/airline limit. Glass dropper bottles require careful packing.
β Frequently Asked Questions
Medik8 states they cannot provide medical advice regarding pregnancy. However, the formula contains no retinoids, high-strength acids, or known harmful ingredients. The low-level PHAs and AHAs (under 3%) are generally considered gentle. Always consult your GP, midwife, or obstetrician before using any new skincare during pregnancy or nursing. Peptides are generally considered safe during pregnancy.
Yes! This serum is verified fungal acne safe by multiple ingredient analysis databases. It's free from oils, fatty acids, ferments, polysorbates, and other ingredients that feed malassezia yeast. The water-based, oil-free formula makes it an excellent choice for those with fungal acne concerns.
Absolutely! Oxy-R Peptides is designed to boost Medik8's CSA (Vitamin C, Sunscreen, Vitamin A) philosophy. In the AM, apply Oxy-R Peptides after cleansing, then your Vitamin C serum, then SPF. In the PM, apply after cleansing, then your retinol or Crystal Retinal. It can also be used with AHAs and BHAs, though introduce slowly to avoid over-exfoliation.
Oxy-R Peptides is suitable for all skin types including sensitive skin - 92% of clinical study participants found it gentle. It's particularly excellent for oily, combination, and acne-prone skin due to its lightweight, oil-free, non-comedogenic formula. Dry skin types should pair with a hydrating moisturizer.
Clinical studies show visible brightness in 7 days. Dark spots begin fading after 4 weeks of consistent use. Significant improvement in overall even tone is clinically proven at 8 weeks. Results vary based on the type and age of pigmentation - recent post-inflammatory marks respond faster than older sun damage or hormonal melasma.
Apply Oxy-R Peptides after cleansing (and toning if you use one), before serums, moisturizers, and SPF. Use 6 drops twice daily - morning and evening. In AM: Cleanser β Oxy-R Peptides β Vitamin C β Moisturizer β SPF. In PM: Cleanser β Oxy-R Peptides β Retinol/Retinal β Moisturizer.
No! Oxy-R Peptides has a comedogenic rating of 0/5. The formula is oil-free, silicone-free, and contains no pore-clogging ingredients. It's water-based with lightweight humectants like hyaluronic acid and glycerin. It's ideal for acne-prone skin and won't contribute to breakouts or congestion.
Each 10ml bottle stays potent for 6 weeks after click-activation. The product comes with two bottles for 12 weeks total treatment. Only activate the second bottle when you finish the first. Store at room temperature away from windows. The short shelf life is due to oxyresveratrol's instability - this is why the patented packaging exists.
This is completely normal! Oxyresveratrol is naturally brown when active in water. Once you click-activate the packaging and the Oxy-R plunges into the water-based solution, the serum takes on a deep brown color. This indicates the active ingredient is now working - it's a sign of potency, not a defect.
No, Oxy-R Peptides does not increase photosensitivity. It's safe for use in both morning and evening routines. However, always use SPF during the day when treating hyperpigmentation - sun exposure is the primary cause of dark spots and will counteract your brightening efforts.
Verdict: Medik8 Oxy-R Peptides is a genuinely innovative brightening serum featuring the highest concentration of stabilized oxyresveratrol available. The patented click-activation technology solves a real formulation challenge, and clinical studies support its efficacy across all skin tones. While the premium price and short shelf life may deter some, those serious about targeting stubborn hyperpigmentation will find this a worthwhile investment. Best for users who can commit to consistent use and want a gentle yet powerful alternative to traditional brightening ingredients like hydroquinone or high-strength Vitamin C.
Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
A professional-strength brightening serum featuring 1% stabilized oxyresveratrol - 33x more effective than kojic acid at inhibiting tyrosinase. This innovative formula combines twin brightening peptides with hyaluronic acid to visibly fade dark spots and even skin tone in as little as 7 days. Patented click-activated packaging ensures maximum potency from first drop to last.
β¨ Texture & Feel
Patented Stabilization System
Click-activated packaging keeps oxyresveratrol stable and potent from first use to last drop - a breakthrough for this notoriously unstable ingredient.
Triple-Threat Brightening
Combines 1% Oxy-R with two brightening peptides (Tetrapeptide-30 & Acetyl Glycyl Beta-Alanine) for comprehensive pigmentation targeting.
All Skin Tones
Clinically tested on diverse panels including Fitzpatrick 5-6 skin types, proving effective and gentle on deeper skin tones.
33x More Effective Than Kojic Acid
Oxyresveratrol is a superior tyrosinase inhibitor according to Journal of Biological Chemistry research.
π‘οΈ Safety & Compatibility
Medik8 advises consulting your GP or midwife before use. While formula contains no known harmful ingredients (no retinoids, high-strength acids), always verify with healthcare provider.
Free from oils, fatty acids, ferments, and polysorbates. Verified fungal acne safe by multiple ingredient analysis databases.
92% of participants in clinical studies found it gentle on their skin. Oxyresveratrol is non-irritating and non-sensitizing.
Does not increase photosensitivity. Safe for AM and PM use. Always use SPF during daytime for best results.
π¬ Ingredient Breakdown
πΏ Oxyresveratrol (Hydroxyresveratrol) 1% Gold-Standard
Naturally derived from the mulberry family, this is one of the most powerful skin-brightening agents available in skincare. It works by inhibiting tyrosinase, the key enzyme responsible for melanin production.
- Research: 33x more effective tyrosinase inhibitor than kojic acid (Journal of Biological Chemistry, 2002)
- Mechanism: Blocks overproduction of melanin that causes dark spots and uneven tone
- Stability: Housed in patented preservation serum in lid until click-activated
𧬠Tetrapeptide-30 0.15-0.55% Proven
An illuminating four-amino-acid peptide that helps minimize the formation of visible dark spots through dual action on the pigmentation pathway.
- Action 1: Acts as a tyrosinase inhibitor to reduce melanin production
- Action 2: Blocks transfer of melanin to upper skin layers
- Clinical Testing: Tested on Caucasian, Asian, and ethnic skin with positive results
β‘ Acetyl Glycyl Beta-Alanine Promising
A brightening peptide that works synergistically with Oxy-R by targeting a different part of the pigmentation process.
- Mechanism: Blocks melanin transport to skin cells, preventing visible pigmentation
- Synergy: Complements Oxy-R for comprehensive "triple-threat" approach
π§ Sodium Hyaluronate 0.55-1.25% Proven
Low molecular weight hyaluronic acid that attracts and retains over 1,000 times its weight in water for deep hydration.
- Function: Delivers hydrating base while optimizing delivery of active ingredients
- Benefit: Leaves complexion visibly nourished and supple
π Gluconolactone (PHA) 2.1-3.1% Gentle
A gentle polyhydroxy acid that provides mild exfoliation without irritation, suitable for sensitive skin.
- Action: Gentle exfoliation helps shed dead cells for smoother skin
- Benefit: Stimulates skin's own hyaluronic acid production
π₯ Lactic Acid (AHA) 0.9-1.4% Gentle
Low concentration alpha hydroxy acid that supports the skin's natural acid mantle and provides humectant benefits.
- Note: Concentration too low for strong exfoliation - works as humectant instead
- pH Optimized: Formula pH designed to minimize degradation of alpha arbutin
15 ingredients
Aqua (Water), Butylene Glycol, Artocarpus Lakoocha Wood Extract, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium EDTA, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
π Where It Fits in Your Routine
Apply after cleansing, before Vitamin C (AM) or Vitamin A/Retinal (PM). Perfect CSA routine booster.
π How to Use
Activate the Serum (First Use Only)
Press down firmly on bottle lid until it clicks. Shake for 30 seconds to blend the Oxy-R into the formula. Recycle lid and replace with dropper.
Cleanse Your Skin
Start with clean, dry skin. Use morning and evening for best results.
Apply 6 Drops
Blend across face, neck, and dΓ©colletage. Avoid the eye area. The serum will have a brown color - this is normal and indicates active Oxy-R.
Allow to Absorb
Wait for serum to fully absorb before applying next products. Follow with Vitamin C (AM) or Vitamin A (PM), then moisturizer.
π€ Who Is It For?
β Perfect for you if:
- You have dark spots from sun damage or aging
- You struggle with post-inflammatory hyperpigmentation (PIH)
- You have uneven skin tone or dullness
- You have melasma concerns
- You want to boost your Vitamin C & A routine
- You have deeper skin tones (Fitzpatrick 4-6)
- You prefer fragrance-free, gentle formulas
β Consider alternatives if:
- You need a budget-friendly option (premium price point)
- You prefer all-in-one products (this is a targeted treatment)
- You want immediate overnight results (patience required)
- You cannot commit to consistent daily use
- You need a product with longer shelf life after opening
π― Skin Type Compatibility
Lightweight, water-based formula absorbs instantly without adding shine or greasiness. Oil-free and silicone-free.
Contains hyaluronic acid and glycerin for hydration, but pair with a rich moisturizer for optimal comfort.
Balances perfectly across different face zones. Hydrates dry areas without overwhelming oily zones.
92% found it gentle in clinical studies. Fragrance-free, non-irritating formula. Patch test recommended for very reactive skin.
Non-comedogenic (0/5 rating), fungal acne safe, oil-free. Ideal for post-acne marks and PIH.
π Results Timeline
Visible Brightness
Skin appears visibly brighter with improved radiance. Hydration levels boosted from hyaluronic acid.
Visible brightness in 7 days*Dark Spot Fading
Post-inflammatory hyperpigmentation and recent dark spots begin to visibly fade. Skin tone appears more even.
Dark spots faded after 4 weeks*Significant Improvement
Clinically proven improvement in overall even tone. Stubborn spots continue to fade with consistent use.
Even tone improved in 8 weeks*Maximum Results
Full benefits realized with continued use. Maintenance application recommended for long-term results.
92% found it gentle on skin*β Ratings by Platform
βοΈ Pros & Cons
β Praised
- Unique 1% oxyresveratrol - highest concentration available
- Patented stabilization ensures potency
- Suitable for all skin tones including deep skin
- Fragrance-free and non-irritating
- Can use with Vitamin C and retinoids
- Lightweight, fast-absorbing texture
- Clinically proven results
- B Corp certified, sustainable brand
β Criticized
- Premium price point (~Β£65/20ml)
- Short 6-week shelf life after opening
- Results require patience (weeks to months)
- Small bottle size for the price
- Click-activation can be confusing
- Brown color after activation unexpected
- Two-bottle system requires remembering to activate second
π° Budget-Friendly Alternatives (Dupes)
Different brightening mechanism (alpha arbutin vs oxyresveratrol) but similar dark spot targeting. Lacks peptides and patented stabilization. Much more affordable for testing brightening serums.
Uses tranexamic acid (3%), niacinamide (5%), and bakuchiol instead of oxyresveratrol. Well-researched alternative approach to hyperpigmentation. Larger 30ml size with longer shelf life.
Uses Viniferine (vine sap extract) claimed to be 62x more effective than Vitamin C. Pregnancy-safe alternative. Different mechanism but similar brightening goals. Larger 30ml bottle.
π Comparison with Competitors
Medik8 Oxy-R Peptides (This Product)
Β£65.00Paula's Choice Clinical Discoloration Repair
$48.00The Ordinary Alpha Arbutin 2% + HA
$12.90Caudalie Vinoperfect Serum
$79.00π¦ Storage & Shelf Life
6 weeks per bottle after activation. Two bottles provided for 12 weeks total treatment. Activate second bottle only when first is finished.
Store at room temperature away from windows and direct sunlight. Keep both bottles at consistent temperature for optimal efficacy.
Patented click-activated dropper bottles. Oxy-R stored separately in lid until activation to preserve stability.
Yes - each 10ml bottle is under 100ml TSA/airline limit. Glass dropper bottles require careful packing.
β Frequently Asked Questions
Medik8 states they cannot provide medical advice regarding pregnancy. However, the formula contains no retinoids, high-strength acids, or known harmful ingredients. The low-level PHAs and AHAs (under 3%) are generally considered gentle. Always consult your GP, midwife, or obstetrician before using any new skincare during pregnancy or nursing. Peptides are generally considered safe during pregnancy.
Yes! This serum is verified fungal acne safe by multiple ingredient analysis databases. It's free from oils, fatty acids, ferments, polysorbates, and other ingredients that feed malassezia yeast. The water-based, oil-free formula makes it an excellent choice for those with fungal acne concerns.
Absolutely! Oxy-R Peptides is designed to boost Medik8's CSA (Vitamin C, Sunscreen, Vitamin A) philosophy. In the AM, apply Oxy-R Peptides after cleansing, then your Vitamin C serum, then SPF. In the PM, apply after cleansing, then your retinol or Crystal Retinal. It can also be used with AHAs and BHAs, though introduce slowly to avoid over-exfoliation.
Oxy-R Peptides is suitable for all skin types including sensitive skin - 92% of clinical study participants found it gentle. It's particularly excellent for oily, combination, and acne-prone skin due to its lightweight, oil-free, non-comedogenic formula. Dry skin types should pair with a hydrating moisturizer.
Clinical studies show visible brightness in 7 days. Dark spots begin fading after 4 weeks of consistent use. Significant improvement in overall even tone is clinically proven at 8 weeks. Results vary based on the type and age of pigmentation - recent post-inflammatory marks respond faster than older sun damage or hormonal melasma.
Apply Oxy-R Peptides after cleansing (and toning if you use one), before serums, moisturizers, and SPF. Use 6 drops twice daily - morning and evening. In AM: Cleanser β Oxy-R Peptides β Vitamin C β Moisturizer β SPF. In PM: Cleanser β Oxy-R Peptides β Retinol/Retinal β Moisturizer.
No! Oxy-R Peptides has a comedogenic rating of 0/5. The formula is oil-free, silicone-free, and contains no pore-clogging ingredients. It's water-based with lightweight humectants like hyaluronic acid and glycerin. It's ideal for acne-prone skin and won't contribute to breakouts or congestion.
Each 10ml bottle stays potent for 6 weeks after click-activation. The product comes with two bottles for 12 weeks total treatment. Only activate the second bottle when you finish the first. Store at room temperature away from windows. The short shelf life is due to oxyresveratrol's instability - this is why the patented packaging exists.
This is completely normal! Oxyresveratrol is naturally brown when active in water. Once you click-activate the packaging and the Oxy-R plunges into the water-based solution, the serum takes on a deep brown color. This indicates the active ingredient is now working - it's a sign of potency, not a defect.
No, Oxy-R Peptides does not increase photosensitivity. It's safe for use in both morning and evening routines. However, always use SPF during the day when treating hyperpigmentation - sun exposure is the primary cause of dark spots and will counteract your brightening efforts.
Verdict: Medik8 Oxy-R Peptides is a genuinely innovative brightening serum featuring the highest concentration of stabilized oxyresveratrol available. The patented click-activation technology solves a real formulation challenge, and clinical studies support its efficacy across all skin tones. While the premium price and short shelf life may deter some, those serious about targeting stubborn hyperpigmentation will find this a worthwhile investment. Best for users who can commit to consistent use and want a gentle yet powerful alternative to traditional brightening ingredients like hydroquinone or high-strength Vitamin C.
